Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

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• 作者：Simonas Rudys ; Carla Rí ; os-Luci ; Eduardo Pé ; rez-Roth ; Inga Cikotiene ; José ; M. Padró ; n
• 关键词：Multicomponent reaction ; Benzob[1 ; 6]naphthyridines ; 1H-Pyrano[4 ; 3-b]quinolines ; Antitumor drugs ; Antibacterial drugs ; Antifungal drugs
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：1 March 2010
• 年：2010
• 卷：20
• 期：5
• 页码：1504-1506
• 全文大小：310 K

文摘

A series of 2-substituted 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzo[b][1,6]naphthyridines were synthesized and their in vitro antiproliferative activities were examined against human solid tumor cell lines and relevant strains of bacteria and Candida. The compounds induced considerably growth inhibition in all cancer cell lines, whilst showed inactive against microbial strains. Furthermore, we found analog 2-ethoxy-1H-pyrano[4,3-b]quinoline as selective inhibitor of microbial strains.