Synthesis of allylic trifluoromethyl alcohols from 1-trifluoromethyl-epoxy ethers

详细信息    查看全文

• 作者：Bé ; gué ; Jean-Pierre ; Bonnet-Delpon ; Daniè ; le ; Kornilov ; Andrei ; Fischer-Durand ; Nathalie
• 关键词：Synthesis ; Allylic trifluoromethyl alcohols ; Epoxy ethers ; α ; -Thiophenyl ketones ; NMR spectroscopy
• 刊名：Journal of Fluorine Chemistry
• 出版年：1996
• 出版时间：September, 1996
• 年：1996
• 卷：80
• 期：1
• 页码：13-16
• 全文大小：334 K

文摘

α-Thiophenyl ketones are easily available by the regioselective ring-opening of 1-trifluoromethyl-epoxy ethers with phenyl sodium thiolate. Their in situ reduction with NaBH₄, followed by oxidation with NaIO₄ and thermal decomposition of the resultant sulphoxides, provided allylic trifluoromethyl alcohols in high overall yield.