Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms
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- 作者：Pierre-Serge Launaya ; b ; c ; 1 ; Elodie Reboussina ; b ; c ; 1 ; Hong Lianga ; b ; c ; d ; Karima Kessala ; b ; c ; David Godefroya ; b ; c ; William Rostenea ; b ; c ; Jose-Alain Sahela ; b ; c ; d ; Christophe Baudouina ; b ; c ; d ; Sté ; phane Melik Parsadaniantza ; b ; c ; Annabelle Reaux Le Goazigoa ; b ; c ; annabelle.reaux@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Benzalkonium chloride ; Corneal neurons ; Ocular pain ; Neuroinflammation ; Trigeminal complex ; Facial motor nucleus
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：16-28
- 全文大小：3132 K
文摘
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BAC induced corneal nerve injury, inflammation and ocular pain.
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Ocular inflammation is associated with activation of FOS and Iba1 in the trigeminal ganglia.
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Chronic ocular inflammation increased peripheral and central pro-inflammatory mediators.
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Microglial p38 activation occurred in sensory trigeminal complex.
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We reported central plastic changes under ocular inflammation.