Effects of prostaglandin E2 on synaptic transmission in the rat spinal trigeminal subnucleus caudalis
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- 作者：Yuka Mizutania ; b ; ag123d26@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshiaki Ohia ; yohi@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Satoko Kimuraa ; s-kimura@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ken Miyazawab ; miyaken@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shigemi Gotob ; shig@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Akira Hajia ; haji@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX2 ; cyclooxygenase 2 ; EPSC ; excitatory postsynaptic current ; IPSC ; inhibitory postsynaptic current ; PGE2 ; prostaglandin E2 ; Vc ; spinal trigeminal subnucleus caudalis ; Vsp ; spinal trigeminal nucleus
- 刊名：Brain Research
- 出版年：2015
- 出版时间：2 November 2015
- 年：2015
- 卷：1625
- 期：Complete
- 页码：29-38
- 全文大小：1458 K
文摘
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PGE2 increased the frequency of sIPSCs and sEPSCs without effect on the amplitude in the Vc neurons.
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This facilitatory action of PGE2 was blocked by an EP1 antagonist but not by an EP4 antagonist.
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PGE2 was ineffective on the trigeminal tract-evoked EPSCs in the Vc neurons.
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PGE2 may modify nociceptive transmission in the Vc neurons through presynaptic EP1 receptors.