A dinuclear silver compound with 5,6,7-trimethyl-[1,2,4]triazolo[1,5-a]pyrimidine with a short Ag–Ag bond. Synthesis, characterization, single-crystal structure analysis and cytostatic activity

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• 作者：Koen Bavelaar^a ; Ramzi Khalil^a ; Ilpo Mutikainen^b ; Urho Turpeinen^b ; Patricia Marqu&#xe8 ; s-Gallego^a ; Mirte Kraaijkamp^a ; Gerard A. van Albada^a ; Jaap G. Haasnoot^a ; Jan Reedijk^a ; ^c ; ^{reedijk@chem.leidenuniv.nl}
• 关键词：Silver ; Cytostatic activity ; Triazolopyrimidine
• 刊名：Inorganica Chimica Acta
• 出版年：2011
• 出版时间：30 January 2011
• 年：2011
• 卷：366
• 期：1
• 页码：81-84
• 全文大小：398 K

文摘

A new dinuclear coordination compound with the ligand 5,6,7-trimethyl[1,2,4]triazolo[1,5-a]pyrimidine (abbreviated as tmtp) is described, together with its 3D crystal structures and spectroscopic properties. The compound shows a high cytostatic activity in ovarian cancer cell lines.

The solid state structure of the compound is dinuclear based, in which the ligand tmtp uses two nitrogens (N3 and N4) to chelate to two different Ag(I) ions. The Ag–Ag distance is relatively short (3.109 Å), but is considered as too long for M–M bonding. The Ag(I) coordination is completed by weakly coordinated, asymmetric bidentate nitrate anions (Ag–O = 2.481–2.819 Å).