High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients
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- 作者：Patrick Y. Kima ; Owen Tana ; Bing Liub ; Toby Trahaira ; b ; Tao Liua ; Michelle Habera ; Murray D. Norrisa ; Glenn M. Marshalla ; b ; g.marshall@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Belamy B. Cheunga ; bcheung@ccia.unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRIM16 ; TDP43 ; Neuroblastoma ; Breast cancer ; Yeast two-hybrid assay
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：374
- 期：2
- 页码：315-323
- 全文大小：1712 K
文摘
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TRIM16 interacts and regulates TDP43 protein levels.
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TDP43 is required for TRIM16 induced cancer cell death.
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TRIM16 and TDP43 together modulate pRb and E2F1 proteins.
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TRIM16 and TDP43 are strong prognostic indicators for neuroblastoma and breast cancer.