Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway
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- 作者：Jacint G. Sanchez1 ; Jessica J. Chiang2 ; Konstantin M.J. Sparrer3 ; Steven L. Alam4 ; Michael Chi1 ; Marcin D. Roganowicz1 ; Banumathi Sankaran5 ; Michaela U. Gack2 ; 3 ; mgack@uchicago.edu" class="auth_mail" title="E-mail the corresponding author ; Owen Pornillos1 ; opornillos@virginia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1315-1325
- 全文大小：3082 K
文摘
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The TRIM25 RING domain dimerizes to make polyubiquitin chains and ubiquitinate RIG-I
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RING domain dimerization is facilitated by higher-order oligomerization of TRIM25
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Higher-order oligomerization of TRIM25 is facilitated by binding to RIG-I 2CARD
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Cooperative assembly of TRIM25 and RIG-I facilitates antiviral signaling