Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity

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• 作者：Inna G. Ovsyannikova^a ; ^d ; Iana H. Haralambieva^a ; ^d ; Robert A. Vierkant^c ; Megan M. O&rsquo ; Byrne^c ; Gregory A. Poland^a ; ^b ; ^d ; ^{poland.gregory@mayo.edu}
• 关键词：MMR ; measles/mumps/rubella ; MV ; measles virus ; CMI ; cell-mediated immunity ; LD ; linkage disequilibrium ; SNP ; single-nucleotide polymorphism ; TRIM ; tripartite motif ; IQR ; interquartile range ; FDR ; false discovery rate ; EM ; expectation-maximization ; MAF ; mi
• 刊名：Human Immunology
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：74
• 期：6
• 页码：768-774
• 全文大小：334 K

文摘

The role of polymorphisms within the antiviral tripartite motif (TRIM) genes in measles vaccine adaptive immune responses was examined. A limited association was found between TRIM5 (rs7122620) and TRIM25 () gene polymorphisms and measles-specific antibody levels. However, many associations were found between TRIM gene SNPs and variations in cellular responses (IFN-¦Ã Elispot and secreted cytokines IL-2, IL-6, IL-10, IFN-¦Ã, and TNF-¦Á). TRIM22 rs2291841 was significantly associated with an increased IFN-¦Ã Elispot response (35 vs. 102 SFC per 2 ¡Á 10⁵ PBMC, p = 0.009, q = 0.71) in Caucasians. A non-synonymous TRIM25 (in LD with other SNPs, r² ? 0.56), as well as the TRIM25 AAAGGAAAGGAGT haplotype, was associated with a decreased IFN-¦Ã Elispot response (t-statistic ?2.32, p = 0.02) in African-Americans. We also identified polymorphisms in the TRIM5, TRIM22, and TRIM25 genes that were associated with significant differences in cytokine responses. Additional studies are necessary to replicate our findings and to examine the functional consequences of these associations.