Trimethylamine-N-Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?

详细信息    查看全文

• 作者：Clara E. Cho¹ ; Marie A. Caudill² ; ^{mac379@cornell.edu}
• 关键词：trimethylamine-N-oxide ; gut microbiome ; flavin-containing monooxygenase 3 ; chronic diseases.
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：121-130
• 全文大小：1528 K
• 卷排序：28

文摘

Trimethylamine-N-oxide (TMAO), a gut-derived metabolite, has recently emerged as a candidate risk factor for cardiovascular disease and other adverse health outcomes. However, the relation between TMAO and chronic disease can be confounded by several factors, including kidney function, the gut microbiome, and flavin-containing monooxygenase 3 (FMO3) genotype. Thus, whether TMAO is a causative agent in human disease development and progression, or simply a marker of an underlying pathology, remains inconclusive. Importantly, dietary sources of TMAO have beneficial health effects and provide nutrients that have critical roles in many biological functions. Pre-emptive dietary strategies to restrict TMAO-generating nutrients as a means to improve human health warrant careful consideration and may not be justified at this time.