Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

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• 作者：Marina Makrecka-Kuka^a ; ^{makrecka@farm.osi.lv} ; Kristine Volska^a ; ^b ; Unigunde Antone^a ; Reinis Vilskersts^a ; ^b ; Solveiga Grinberga^a ; Dace Bandere^b ; Edgars Liepinsh^a ; Maija Dambrova^a ; ^b
• 关键词：ETS capacity ; electron transfer system capacity ; FCR ; flux control ratio ; LEAK respiration ; substrate-dependent respiration ; OXPHOS respiration ; ADP-stimulated oxidative phosphorylation dependent ; ROS ; reactive oxygen species ; ROX ; residual oxygen consumption ; TMAO ; trimethylamine N-oxide
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：32-38
• 全文大小：771 K
• 卷排序：267

文摘

Trimethylamine-N-oxide (TMAO) impairs β-oxidation in cardiac mitochondria. TMAO decreases pyruvate metabolism via impaired substrate flux. Increased TMAO content induces energy metabolism disturbances in the heart. Increased TMAO concentration is a risk factor for heart failure progression.