Synthesis of trimethylsilyl carboxylates by HMDS under solvent-free conditions

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• 作者：Marjan Jereb ; ^{marjan.jereb@fkkt.uni-lj.si" class="auth_mail" title="E-mail the corresponding author} ; Janja Lakner
• 关键词：Carboxylic acids ; HMDS ; Trimethylsilyl carboxylates ; Solvent-free
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：72
• 期：37
• 页码：5713-5723
• 全文大小：745 K

文摘

A broad set of structurally different carboxylic acids were transformed into their trimethylsilyl esters with HMDS in a practically completely solvent-free process, while a catalytic amount of iodine was required in some cases. The process has several advantages over the known methods: untreated reactants, air atmosphere, mild and neutral conditions, no evolution of hydrogen halide, no need of an additional base, low amount of waste, completely without chromatography, low consumption of energy, and operational simplicity.