Microwave-assisted copper- and palladium-catalyzed sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene

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• 作者：Yonghua Lei^a ; ^&dagger ; ; Tianhan Hu^a ; ^&dagger ; ; Xingsen Wu^a ; Yue Wu^a ; Hua Xiang^a ; Haopeng Sun^a ; Qidong You^a ; ^{youqd@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaojin Zhang^a ; ^b ; ^{zxj@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Trimethylsilylacetylene ; Microwave ; Sonogashira
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：9 March 2016
• 年：2016
• 卷：57
• 期：10
• 页码：1100-1103
• 全文大小：3162 K

文摘

An efficient and rapid method was developed for the synthesis of 1-aryl-2-(trimethylsilyl)acetylene. Copper and palladium-catalyzed sonogashira-type coupling of trimethylsilylacetylene and aryl bromides or iodides in the presence of triethylamine as base under microwave irradiation in acetonitrile afforded the desired 1-aryl-2-(trimethylsilyl)acetylene. The use of microwave was found to significantly improve the reaction yield and shorten the reaction time.