Reinvestigation of ortho-amidoacetophenones' cyclization mediated by trimethylsilyl trifluoromethanesulfonate. The Lewis-acid-assisted and Brønsted-acid-catalyzed reaction

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• 作者：Yi-Ru Chen ; Yu Cheng Cho ; Tzenge-Lien Shih ; ^{tlshih@mail.tku.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Methylquinoline ; Quinolone ; Trifluoromethanesulfonic acid ; Trimethylsilyl trifluoromethanesulfonate ; Lewis-acid-assisted and Brø ; nsted-acid-catalyzed reaction
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：21 April 2016
• 年：2016
• 卷：72
• 期：16
• 页码：2006-2011
• 全文大小：685 K

文摘

Reinvestigation the synthesis of quinolones from ortho-amidoacetophenones by trimethylsilyl trifluoromethanesulfonate (TMSOTf) mediated reaction is reported. In addition to receiving the expected quinolones, an unexpected intermolecular self-condensation adduct was also isolated. The detailed mechanism of its formation is discussed.