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• 作者：Krisana Peewasan ; Chutima Kuhakarn ; Darunee Soorukram ; Patoomratana Tuchinda ; Vichai Reutrakul ; Manat Pohmakotr ; ^{scmpk@mahidol.ac.th}
• 关键词：¦Á ; ¦Á-Difluoro-¦Á-phenylsulfanyl-¦Á-trimethylsilylmethane ; gem-Difluoromethylenated cyclopentanols ; Radical cyclization
• 刊名：Journal of Fluorine Chemistry
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：135
• 期：Complete
• 页码：367-372
• 全文大小：632 K

文摘

A general strategy for the preparation of gem-difluoromethylenated cyclopentanols has been demonstrated; it involves sequential fluoride-catalyzed nucleophilic addition of ¦Á,¦Á-difluoro-¦Á-phenylsulfanyl-¦Á-trimethylsilylmethane (PhSCF₂SiMe₃; 1) to homoallyl ketones followed by intramolecular radical cyclization.