Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
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- 作者：Ernesto Miquela ; Adriana Cassinab ; c ; Laura Martí ; nez-Palmaa ; José ; M. Souzab ; c ; Carmen Bolattoa ; Sebastiá ; n Rodrí ; guez-Botteroa ; Angela Logand ; Robin A.J. Smithe ; Michael P. Murphyd ; Luis Barbeitof ; Rafael Radib ; c ; Patricia Cassinaa ; c ; pcassina@fmed.edu.uy" class="auth_mail
- 关键词：ALS ; amyotrophic lateral sclerosis ; SOD1G93A ; ALS-linked superoxide dismutase 1 bearing the G93A mutation ; MitoQ ; [10-(4 ; 5-dimethoxy-2-methyl-3 ; 6-dioxo-1 ; 4-cyclohexadien-1-yl)decyl]triphenylphosphonium ; TPP ; triphenylphosphonium ; decylTPP ; decyltriphenylphosphonium cation ; LC/ESI&ndash ; MS/MS ; liquid chromatography/electrospray ionization&ndash ; mass spectrometry ; MRM ; multiple-reaction monitoring ; d15-MitoQ ; deuterated MitoQ ; IS ; internal standard ; FCCP ; carbonyl cyanide p-trifluoromethoxyphenylh
- 刊名：Free Radical Biology and Medicine
- 出版年：May 2014
- 年：2014
- 卷：70
- 期：Complete
- 页码：204-213
- 全文大小：6137 K
文摘
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We examined the effects of the mitochondria-targeted antioxidant MitoQ on disease progression in a mouse model of ALS.
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MitoQ slowed the mitochondrial functional decline in the spinal cord and muscle.
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MitoQ decreased nitroxidative damage in the nervous system.
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MitoQ treatment increased survival and slowed the progression of ALS symptoms.