MYC and metabolism on the path to cancer
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- 作者：Annie L. Hsieha ; b ; c ; Zandra E. Waltona ; b ; Brian J. Altmana ; b ; Zachary E. Stinea ; b ; Chi V. Danga ; b ; d ; dangvchi@exchange.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-DG ; 2-deoxyglucose ; 4E-BP ; eIF4E-binding protein ; 5 ; 10-methylene THF ; 5 ; 10-methylenetetrahydrofolate ; ACC ; acetyl-CoA carboxylase ; ACLY ; ATP-citrate lyase ; AMPK ; AMP-activated protein kinase ; ATP ; adenosine triphosphate ; ChIP-seq ; chromatin immunoprecipitation sequencing ; ChREBP ; carbohydrate response element binding protein ; CRY ; cryptochrome ; DOX ; doxycycline ; eIF4E ; eukaryotic initiation factor 4E ; FADH ; flavin adenine dinucleotide ; FAO ; fatty acid β-oxidation ; FASN ; fatty acid synthase ; FO
- 刊名：Seminars in Cell & Developmental Biology
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：43
- 期：Complete
- 页码：11-21
- 全文大小：3101 K
文摘
- 5">
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5">The MYC proto-oncogene is commonly deregulated and activated in human cancers.
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MYC-dependent metabolism is critical for tumor growth.
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5">MYC alters metabolism through both transcriptional and posttranscriptional regulations.
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Interplay between MYC and mTOR is essential in rapidly growing cells.