Triple signal amplification strategy based on size and shape transformation of ultrasmall sub-10 nm gold nanoparticles tag towards sensitivity improvement of electrochemical immunosensors
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- 作者：Pattasuda DuangkaewAuthor Vitae ; Tuksadon WutikhunAuthor Vitae ; Rawiwan Laocharoensuk ; rawiwan.lao@nanotec.or.th" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Triple signal amplification ; Ultrasmall gold nanoparticles tag ; Gold enhancer ; Silver enhancer ; Electrochemical detection ; Immunosensors
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：239
- 期：Complete
- 页码：430-437
- 全文大小：1320 K
文摘
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Ultrasmall sub-10 nm AuNPs tags coupled with triple signal amplification process leads to over 260-fold of signal increase in comparison with conventional silver enhancement process.
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This process yields over 3-order of magnitude sensitivity improvement.
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Principle of successive triple amplification is applicable for existing AuNP-based bioassays.