Regioselective routes towards 14-hydroxyabietane diterpenes. A formal synthesis of immunosuppressant (−)-triptolide from (+)-abietic acid
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- 作者：Enrique Alvarez-Manzaneda ; Rachid Chahboun ; Faouzia Bentaleb ; Esteban Alvarez ; M. Angeles Escobar ; Said Sad-Diki ; Maria José ; Cano ; Ibtissam Messouri
- 关键词：RNA synthesis ; Hydroxyl protecting group ; β ; -Elimination ; siRNA
- 刊名：Tetrahedron
- 出版年：2007
- 出版时间：5 November 2007
- 年：2007
- 卷：63
- 期：45
- 页码：11204-11212
- 全文大小：362 K
文摘
Two procedures to introduce an oxygenated function into the C-14 of abietane diterpenes with complete regioselectivity have been developed. Utilizing these, the synthesis of the antileishmanial quinone (−)-12-deoxyroyleanone (1) and a formal synthesis of antitumour and immunosuppressant (−)-triptonide (7) and (−)-triptolide (8) from (+)-abietic acid (13) have been carried out.