Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (−)-triptolide

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• 作者：Bing Zhou ; Xiaomei Li ; Huijin Feng ; Yuanchao Li
• 关键词：Triptophenolide methyl ether ; (− ; )-Triptolide ; (− ; )-Triptonide ; Abietic acid ; Total synthesis
• 刊名：Tetrahedron
• 出版年：2010
• 出版时间：17 July 2010
• 年：2010
• 卷：66
• 期：29
• 页码：5396-5401
• 全文大小：234 K

文摘

An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (−)-triptolide 1. The route is of characteristic of low cost, high yield and easy operation. In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield.