Post-translational regulation by structural changes of 4-dihydromethyltrisporate dehydrogenase, a key enzyme in sexual and parasitic communication mediated by the trisporic acid pheromone system, of the fungal fusion parasite Parasitella parasitica

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• 作者：Sabrina Ellenberger^a ; ^{Sabrina.Ellenberger@uni-jena.de} ; Anke Burmester^a ; Stefan Schuster^b ; Johannes Wö ; stemeyer^a
• 关键词：Bifunctional pheromone system ; Protein-protein docking ; Sexual development ; Structure prediction ; Trisporic acid
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：21 January 2017
• 年：2017
• 卷：413
• 期：Complete
• 页码：50-57
• 全文大小：847 K
• 卷排序：413

文摘

Sexual and parasitic communication are mediated by the same trisporic acid system. Switch from sexual to parasitic communication is regulated post-translationally. TSP1 contains three structure elements which determine dimerization specificity. TSP1 for sexual communication like in other zygomycetes forms inactive homodimers. TSP1 for parasitic communication in Parasitella parasitica forms active homodimers.