Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production
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- 作者：Mauricio Cortes1 ; Michael J. Chen2 ; David L. Stachura3 ; Sarah Y. Liu1 ; Wanda Kwan1 ; Francis Wright3 ; Linda T. Vo2 ; Lindsay N. Theodore1 ; Virginie Esain1 ; Isaura M. Frost1 ; Thorsten M. Schlaeger2 ; Wolfram Goessling4 ; 5 ; George Q. Daley2 ; 5 ; Trista E. North1 ; 5 ; 6 ; tnorth@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：vitamin D ; 1 ; 25(OH)D3 ; hematopoietic stem cell (HSC) ; cxcl8 ; zebrafish ; hUCB ; CFU-C
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：458-468
- 全文大小：3211 K
文摘
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Developmental 1,25(OH)D3 availability modulates definitive HSPC production
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The effect of 1,25(OH)D3 on HSPCs is VDR-mediated and Ca2+-independent
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Vitamin D supplementation significantly increases human UCB HSPCs in vitro
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1,25(OH)D3 exposure promotes viability and proliferation via Cxcl8 (IL-8) activity