Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum

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• 作者：Ning Li^a ; ^d ; Chun-Fu Wu^b ; Xin-Yue Xu^c ; Zhen-Yang Liu^c ; Xian Li^a ; ^d ; Yu-Qing Zhao^a ; ^d ; ^{zhaoyuqingsypharm@163.com}
• 关键词：Novel triterpenes ; Hydrolyzate ; Saponins from Gynostemma pentaphyllum ; Antitumor
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：50
• 期：Complete
• 页码：173-178
• 全文大小：332 K

文摘

Five novel triterpenes were isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum and identified as gypensapogenin A (1), gypensapogenin B (2), gypensapogenin C (3), 3-O-¦Â-d-glucopyranosyl-gypensapogenin D (4) and gypensapogenin D (5), two of which (1 and 2) possess unprecedented ring A. The cyclization of the side chains-3 formed five-membered cyclic ketone rings similar to ring E in 1. The 21-oic acid-21, 23-lactone was present in the side chains of 4 and 5. We also proposed the possible formation mechanisms of compounds 1-3. Compounds 1-5 were evaluated for cytotoxic activities in three cell lines including A549, U87 and Hep3B and compound 3 showed significant activities toward A549 and U87 human cancer cells (with IC 50 values at 0.11 and 0.58?¦Ìm respectively).