- 作者：Vincent Leroy ; Marie-Noë ; lle Hilleret ; Nathalie Sturm ; C ; ice Trocme ; Jean-Charles Renversez ; Patrice Faure ; Franç ; oise Morel ; Jean-Pierre Zarski
- 关键词：PIIINP ; Metalloproteinase ; Fibrotest ; Fibrometer ; APRI ; METAVIR ; Fibrosis
- 刊名：Journal of Hepatology
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：46
- 期：5
- 页码：775-782
- 全文大小：437 K
Background/Aims
Non-invasive markers of liver fibrosis have recently been developed as an alternative to liver biopsy. The aim of this study was to compare the diagnostic performance of 6 scores (MP3, Fibrotest, Fibrometer, Hepascore, Forns’ score and APRI).Methods
We studied 180 chronic hepatitis C patients. Liver fibrosis was staged according to the METAVIR scoring system.
Results
Overall diagnostic performance of scores determined by AUROCs ranged from 0.86 for Fibrometer to 0.78 for Forns’ score (NS) for discriminating F0F1 versus F2F3F4. For discriminating F0F1F2 versus F3F4, AUROCs ranged from 0.91 for Fibrometer to 0.78 for Forns’ score (p < 0.02). Significant or extensive fibrosis was predicted in 10–86 % of patients with positive predictive value (PPV) ranging from 55 % to 94 % . Using logistic regression, statistical independence was demonstrated for MP3, Fibrotest and APRI. Diagnostic performance of paired-combination scores was then evaluated. The best combinations could select one-third of patients for whom either absence of significant fibrosis or presence of extensive fibrosis could be predicted with more than 90 % of certainty.
Conclusions
Current non-invasive scores give reliable information on liver fibrosis in one-third of chronic hepatitis C patients, especially when used in combination.