Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides
详细信息    查看全文
文摘

Twelve new derivatives of trolox, trolox succinate, and α-tocopheryl succinate containing nitroxyl radicals were analyzed.

A cytotoxicity was tested in human tumor cells: myeloma, adenocarcinoma, hepatocarcinoma, T cells leukemia, histiocytic, lymphoma, and T-cellular leucosis.

Several trolox and α-tocopherylsuccinate nitroxides may be promising in parallel as antioxidants and as specific inhibitors of some tumor cells growth.

For suppressing of the growth tumor and normal cells the compounds should have in the molecules fragments of TroH, TroS or α-TOS.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700