Twelve new derivatives of trolox, trolox succinate, and α-tocopheryl succinate containing nitroxyl radicals were analyzed.
A cytotoxicity was tested in human tumor cells: myeloma, adenocarcinoma, hepatocarcinoma, T cells leukemia, histiocytic, lymphoma, and T-cellular leucosis.
Several trolox and α-tocopherylsuccinate nitroxides may be promising in parallel as antioxidants and as specific inhibitors of some tumor cells growth.
For suppressing of the growth tumor and normal cells the compounds should have in the molecules fragments of TroH, TroS or α-TOS.