Molecular analysis of the HuD gene in neuroendocrine lung cancers
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- 作者：Vito D’ ; Aless ; ro ; Lucia Anna Muscarella ; Annamaria la Torre ; Michele Bisceglia ; Paola Parrella ; Gerardo Scaramuzzi ; Clelia Tiziana Storlazzi ; Domenico Trombetta ; Klaas Kok ; Angelo De Cata ; Marco
- 关键词：ELAV-like ; HuD ; Mutation ; Neuroendocrine tumor ; Carcinoid ; SCLC ; Lung cancer
- 刊名：Lung Cancer
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：67
- 期：1
- 页码：69-75
- 全文大小：1006 K
文摘
n-ELAV (neuronal-Embryonic Lethal, Abnormal Vision)-like genes belong to a family codifying for onconeural RNA-binding proteins, also called Hu antigens. Anti-Hu-antibodies (anti-Hu-Ab) are typically associated with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/PSN), and low titres of anti-Hu-Ab were found in neural/neuroendocrine neoplasms, especially small cell lung cancer (SCLC). To date, few studies have been published focused on the genetic causes of their involvement in the pathogenesis of neuroendocrine tumors (NE).
Here we analyzed 20 primary human neuroendocrine lung tumor tissues for somatic mutations in the HuD gene. Two inactivating mutations (a frameshift and a stop codon mutation) and 11 nucleotide changes were detected in the coding sequence of HuD gene in 7 different lung tumors. Our results on SCLC and carcinoid tissues support the hypothesis that alterations of nELAV genes could be involved in the onset and/or progression of a subset of neuroendocrine lung tumors.