Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
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- 作者：Cristian A. Lasagna-Reeves1 ; 2 ; Maria de Haro1 ; 2 ; Shuang Hao1 ; 3 ; Jeehye Park1 ; 2 ; 10 ; Maxime W.C. Rousseaux1 ; 2 ; Ismael Al-Ramahi1 ; 2 ; Paymaan Jafar-Nejad1 ; 2 ; 11 ; Luis Vilanova-Velez1 ; 2 ; Lauren See1 ; 2 ; Antonia De Maio1 ; 2 ; 4 ; Larissa Nitschke1 ; 2 ; 5 ; Zhenyu Wu1 ; 3 ; Juan C. Troncoso6 ; Thomas F. Westbrook2 ; 4 ; 5 ; 7 ; 8 ; Jianrong Tang1 ; 3 ; Juan Botas1 ; 2 ; Huda Y. Zoghbi1 ; 2 ; 4 ; 5 ; 9 ; 12 ; hzoghbi@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：tau levels ; neurodegeneration ; tau phosphorylation ; Nuak1
- 刊名：Neuron
- 出版年：2016
- 出版时间：19 October 2016
- 年：2016
- 卷：92
- 期：2
- 页码：407-418
- 全文大小：3086 K
文摘
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The AMPK-related kinase Nuak1 regulates tau levels
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Nuak1 is associated with tau pathology in AD and PSP patients
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Nuak1 directly phosphorylates tau at serine 356
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Reduction of Nuak1 rescues the phenotypes in tauopathy models