A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

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• 作者：Nicholas T. Seyfried¹ ; ² ; ⁸ ; ⁹ ; ^{nseyfri@emory.edu} ; Eric B. Dammer¹ ; ⁸ ; Vivek Swarup³ ; Divya Nandakumar¹ ; Duc M. Duong¹ ; Luming Yin¹ ; Qiudong Deng¹ ; Tram Nguyen¹ ; Chadwick M. Hales² ; Thomas Wingo² ; ⁷ ; Jonathan Glass² ; Marla Gearing⁴ ; Madhav Thambisetty⁵ ; ⁶ ; Juan C. Troncoso⁵ ; Daniel H. Geschwind³ ; James J. Lah² ; Allan I. Levey² ; ^{alevey@emory.edu}
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：60-72.e4
• 全文大小：2373 K
• 卷排序：4

文摘

Protein modules correlated with cognition and Alzheimer’s disease (AD) pathology Modules associated with brain cell types overlapped in protein and RNA networks Many protein-based modules were distinct from those in RNA-directed networks AD risk loci converged in glial-related modules in the proteome and transcriptome