Calcium signaling in membrane repair

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• 作者：Xiping Cheng ; ^{xiping.cheng@regeneron.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaoli Zhang ; Lu Yu ; Haoxing Xu ; ^{haoxingx@umich.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：TRPML1 ; Ca2+ ; Lysosomal exocytosis ; Calcium sensor ; Membrane repair
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：45
• 期：Complete
• 页码：24-31
• 全文大小：1549 K

文摘

Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM) disruptions occur. Models of PM repair mechanisms include the “lipid-patch”, “endocytic removal”, and “macro-vesicle shedding” models, all of which postulate a dependence on local increases in intracellular Ca²⁺ at injury sites. Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca²⁺ may regulate multiple steps of the repair process. Although earlier studies focused exclusively on external Ca²⁺, recent studies suggest that Ca²⁺ release from intracellular stores may also be important for PM resealing. Hence, depending on injury size and the type of injury, multiple sources of Ca²⁺ may be recruited to trigger and orchestrate repair processes. In this review, we discuss the mechanisms by which the resealing process is promoted by vesicular Ca²⁺ channels and Ca²⁺ sensors that accumulate at damage sites.