Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats

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• 作者：Misael Gonzá ; lez-Ramí ; rez ; Leó ; n I. Razo-Juá ; rez ; José ; L. Sauer-Ramí ; rez ; Ma. Eva Gonzá ; lez-Trujano ; Hermelinda Salgado-Ceballos ; S ; ra Orozco-Suarez
• 关键词：Vitamin C ; Progesterone ; Myoclonic seizures ; Clonic seizures ; Tonic seizures ; Inhibitory amino acid ; Excitatory amino acid
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：97
• 期：2
• 页码：267-272
• 全文大小：359 K

文摘

Vitamin C helps to prevent brain oxidative stress and participate in the synthesis of progesterone. It also possesses a progesterone-like effect and acts synergistically with progesterone on the brain. Progesterone and its metabolites, but also vitamin C have been associated with anticonvulsant effects. We evaluated the progesterone concentration 30 min and 24 h after the last administration of vitamin C (500 mg/kg, i.p. for five days). We also evaluated how vitamin C altered pentylenetetrazol (PTZ)-induced seizures by measuring the onset latency of seizures, percentage of incidence and mortality as well as amino acid levels after seizures. Vitamin C treatment alone increased basal progesterone concentrations to 531 % after 30 min compared to 253 % after 24 h. Furthermore, vitamin C significantly increased the latency to the first myoclonic, clonic and tonic seizure induced by PTZ (80 mg/kg, i.p.) and decreased the percentage of incidence of clonic and tonic seizures as well as the mortality rate. Changes in tissue concentration of amino acids were primarily observed at 24 h after vitamin C treatment. Our results suggest that vitamin C together with progesterone and/or its metabolites are involved in the protection against PTZ-induced seizures in immature rats.