Surfactant-assisted size control of hydroxyapatite nanorods for bone tissue engineering

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• 作者：Nguyen Kim Nga^a ; ^{nga.nguyenkim@hust.edu.vn" class="auth_mail} ; Luu Truong Giang^a ; Tran Quang Huy^b ; Pham Hung Viet^c ; Claudio Migliaresi^d
• 关键词：Hydroxyapatite nanorods ; Pluronic ; SBF ; Bioactivity ; Bone tissue engineering
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：1 April, 2014
• 年：2014
• 卷：116
• 期：Complete
• 页码：666-673
• 全文大小：2712 K

文摘

This study presents the physicochemical characterization of the pluronic surfactant-assisted size control of hydroxyapatite (HAp) nanorods for bone tissue engineering (BTE). Rod-shaped HAp nanoparticles were synthesized via a simple route by hydrothermal treatment and with the assistance of the triblock co-polymer PEO₂₀-PPO₇₀-PEO₂₀ (P123). The films of poly (d, l) lactic acid (PDLLA) were prepared as a substrate to spread synthesized HAp nanorods. Powder X-ray diffraction (XRD), field electron scanning microscopy, Fourier transform infrared spectroscopy, nitrogen adsorption isotherms, and energy-dispersive X-ray spectroscopy were used to characterize the structure and composition of the HAp samples. Results showed that regular rod-shaped HAp nanoparticles (with a mean length of 120 nm and a mean width of 28 nm) were successfully produced. Moreover, synthesized HAp nanorods revealed the rapid formation of bone-like apatite with a distinctive morphology, similar to flower-like apatite; the formation was observed as early as 7 days after incubation in stimulated body fluids. This study is a positive addition to the ongoing research on the preparation of HAp nanostructures toward the development of biocompatible composite scaffolds for BTE applications.