Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase
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- 作者：Shashi S. Sumana ; Asif Equbala ; Amir Zaidia ; Md. Yousuf Ansarib ; e ; Krishn Pratap Singha ; Kuljit Singha ; e ; Bidyut Purkaitd ; Ganesh Chandra Sahoob ; Sanjeeva Bimalc ; Pradeep Dasd ; Vahab Alia ; b ; vahab_ali@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leishmania donovani ; Trypanothione ; Thiol metabolism ; Tryparedoxin ; Tryparedoxin peroxides ; Drug resistance
- 刊名：Biochimie
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：312-325
- 全文大小：1548 K
文摘
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We characterized Ld-cTXN and Ld-cTXNPx of thiol metabolic pathway.
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Ld-cTXN interacts with Ld-cTXNPx protein as demonstrated by in-vivo and in-silico analysis.
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Ld-cTXN expression is upregulated in AmpB-resistant isolates of L. donovani.