Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates
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- 作者：Susan Wyllie ; Goutam M ; al ; Neeloo Singh ; Shyam Sundar ; Alan H. Fairlamb ; Mitali Chatterjee
- 关键词：Antimonial resistance ; Leishmania donovani ; Tryparedoxin peroxidase
- 刊名：Molecular and Biochemical Parasitology
- 出版年：2010
- 出版时间：October 2010
- 年：2010
- 卷：173
- 期：2
- 页码：162-164
- 全文大小：143 K
文摘
Enhancement of the anti-oxidant metabolism of Leishmania parasites, dependent upon the unique dithiol trypanothione, has been implicated in laboratory-generated antimony resistance. Here, the role of the trypanothione-dependent anti-oxidant pathway is studied in antimony-resistant clinical isolates. Elevated levels of tryparedoxin and tryparedoxin peroxidase, key enzymes in hydroperoxide detoxification, were observed in antimonial resistant parasites resulting in an increased metabolism of peroxides. These data suggest that enhanced anti-oxidant defences may play a significant role in clinical resistance to antimonials.