Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host
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- 作者：Mariana Bonillaa ; Erika Krulla ; Florencia Irigoí ; nb ; d ; Gustavo Salinasc ; e ; gsalin@fq.edu.uy" class="auth_mail" title="E-mail the corresponding author ; Marcelo A. Cominia ; mcomini@pasteur.edu.uy" class="auth_mail" title="E-mail the corresponding author
- 关键词：GLO2 ; glyoxalase II or hydroxyacylglutathione hydrolase ; Grx1 ; monothiol glutaredoxin 1 ; Grx3 ; monothiol glutaredoxin 3 ; MG ; methylglyoxal ; TXN ; tryparedoxin ; TXN-Px ; tryparedoxin peroxidase ; PDO ; persulfide dioxygenase ; PSTK ; phosphoseryl-tRNASec kinase ; SDO ; sulfur dioxygenase ; Sec ; selenocysteine ; SepSecS ; Sec-tRNA synthase ; SPS2 ; selenophosphate syntethase ; SQR ; sulfide quinone oxidoreductase ; STS ; sulfurtransferase ; TR ; trypanothione reductase
- 刊名：Molecular & Biochemical Parasitology
- 出版年：2016
- 出版时间：March-April 2016
- 年：2016
- 卷：206
- 期：1-2
- 页码：13-19
- 全文大小：1109 K
文摘
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All trypanosomatids harbor genes for selenocysteine incorporation into proteins.
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Three selenoprotein genes were inherited from a free-living trypanosomatid ancestor.
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The subgenus Viannia of Leishmania lacks a trypanosomatid-specific selenoprotein.
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Trypanosomatid selenoproteins are not involved in oxidative defense.
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Selenoproteins are dispensable for survival of African trypanosomes in mice.