Immunogenicity and protective efficacy of Pseudomonas aeruginosa type a and b flagellin vaccines in a burned mouse model
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- 作者：Parisa Laghaeia ; Farhad B. Hashemib ; Gholamreza Irajiana ; ghirajian.vac@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fatemeh Korpia ; Nour Amirmozafaria ; Bahador Behrouzb ; bahador.behroz3@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：flagellins ; type a and b flagellins ; MDR ; LB ; Luria Bertani ; IL ; interleukin ; DC ; dendritic cells ; TSA ; trypticase soy agar ; TSB ; tryptic soy broth ; s.c ; subcutaneously ; PBS ; phosphate buffered saline ; CFU ; colony-forming unit ; FBS ; fetal bovine serum ; HRP ; horseradish peroxidase ; ELISA ; enzyme-linked immunosorbent assay ; T-PBS ; tween-PBS ; BSA ; bovine serum albumin ; PMNS ; polymorphonuclear leukocytes ; NMS ; normal mouse serum
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：71-81
- 全文大小：2431 K
文摘
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The first report of protection against P. aeruginosa infection by flagellins.
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P. aeruginosa flagellins induces antigen-specific immune responses.
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Flagellins elicits opsono-phagocytic antibodies that inhibit of P. aeruginosa motility.
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Immunization with flagellins increased production of IL-12 and suppressed IL-10.
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Flagellins immunization can improve survival rate of mice with wound infection.