Polyether nanoparticles from covalently crosslinked copolymer micelles

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• 作者：Maria Jamró ; z-Piegza ; Wojciech Wał ; ach ; Andrzej Dworak ; Barbara Trzebicka
• 关键词：Block copolymer ; Self-assembly ; Polymeric micelles ; Micelle crosslinking ; Nanogel
• 刊名：Journal of Colloid and Interface Science
• 出版年：2008
• 出版时间：1 September 2008
• 年：2008
• 卷：325
• 期：1
• 页码：141-148
• 全文大小：662 K

文摘

Double hydrophilic block copolymers poly(ethylene oxide)-b-polyglycidol were synthesized using living anionic polymerization. The polyglycidol blocks were made hydrophobic by the esterification of a part of hydroxyl groups with cinnamic acid, thus simultaneously attaching UV-sensitive double bonds to the polymer backbone. The block copolymers were found to spontaneously associate in aqueous solution forming well-defined micelles, where the corona of the micelles was formed of EO units and the cores consisted of hydrophobic glycidyl cinnanamate units. The critical micelle concentration was determined by light-scattering measurements and fluorescence spectroscopy. Stabilization of micelles was obtained by covalently crosslinking the cores of polyether micelles formed from amphiphilic block copolymers of the type poly(ethylene oxide)-b-poly(glycidol-co-glycidyl cinnamate) (denoted EO₁₁₃-b-(Gl₃₃-co-GlCA_33−x)). To obtain stable nanoparticles double bonds of cinnamate units contained in core were crosslinked under UV irradiation. The kinetics of the stabilization process was investigated using SEC-MALLS and UV spectroscopy. The parameters of the micelles and nanogels were calculated from the light-scattering data.