Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

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• 作者：Yen-Ta Lu^a ; ¹ ; Tien-Ling Chen^b ; ¹ ; Kuo-Song Chang^d ; ^e ; Chia-Ming Chang^c ; Tsai-Yin Wei^c ; Jen-Wei Liu^f ; Chih-Ang Hsiao^f ; Tzenge-Lien Shih^f ; ^{tlshih@mail.tku.edu.tw}
• 关键词：Benzazole ; B16F10 cells ; Melanoma ; MTS assay ; Naphthalimide ; Topoisomerase II
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：25
• 期：2
• 页码：789-794
• 全文大小：832 K
• 卷排序：25

文摘

Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.