- 作者：Hu-Yuan Tsai ; Jyh-Hong Lee ; Hsin-Hui Yu ; Li-Chieh Wang ; Yao-Hsu Yang ; Bor-Luen Chiang ; gicmbor@ntu.edu.tw
- 关键词：systemic juvenile idiopathic arthritis ; systemic onset juvenile rheumatoid arthritis
- 刊名：Journal of the Formosan Medical Association
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：111
- 期：10
- 页码：542-549
- 全文大小：366 K
Background/Purpose
The diagnosis of systemic onset juvenile idiopathic arthritis (SoJIA) on disease onset is challenging and made mainly by exclusion. This study aimed to investigate the initial clinical and laboratory features of children with SoJIA in Taiwan.Methods
Patients diagnosed with SoJIA at the National Taiwan University Hospital between 1997 and 2007 were evaluated and data were collected by retrospective chart review. Inferential statistics were used to compare features of patients with steroid use for <6 months or >6 months.
Results
Twenty-eight (28) patients (13 boys and 15 girls) were included in this study. The mean age of onset was 8.7 years old. The most common presentations were fever (100 % ), arthritis (89.3 % ), and skin rash (67.9 % ). The patterns of arthritis in affected patients were 50 % oligoarticular type and 39 % polyarticular type. The most common joints involved were the knee (76 % of patients with arthritis), ankle (56 % ), and elbow and proximal interphalangeal joints (28 % ). The most common pattern of fever during first week was intermittent (53 % ). Prolonged use of steroid was associated with leukocytosis (17.63 ¡À 7.71 vs. 11.93 ¡À 4.43 ¡Á 109 leukocytes/L, p < 0.05) and higher aspartate aminotransferase (89.4 vs. 31.2 U/L, p < 0.05) on initial presentation.
Conclusion
In SoJIA, extra-articular features such as fever, rash, and lymphadenopathy are most prominent. Leukocytosis and polyarticular pattern on presentation may indicate a refractory clinical course.