Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay

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• 作者：Kallirroi Voudouri^a ; Dragana Nikitovic^a ; Aikaterini Berdiaki^a ; John Tsiaoussis^a ; Dimitris Kletsas^b ; Nikos K. Karamanos^c ; George N. Tzanakakis^a ; ^{tzanakak@uoc.gr}
• 关键词：Breast cancer cell adhesion ; Fibronectin ; Insulin growth factor receptor &ndash ; I (IGF-IR) ; p53 tumor suppressor gene
• 刊名：Data in Brief
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：Complete
• 页码：568-572
• 全文大小：398 K
• 卷排序：9

文摘

In this data article, the potential role of p53 tumor suppressor gene (p53) on the attachment ability of MCF-7 breast cancer cells was investigated. In our main article, “IGF-I/ EGF and E2 signaling crosstalk through IGF-IR conduit point affect breast cancer cell adhesion” (K. Voudouri, D. Nikitovic, A. Berdiaki, D. Kletsas, N.K. Karamanos, G.N. Tzanakakis, 2016) [1], we describe the key role of IGF-IR in breast cancer cell adhesion onto fibronectin (FN). p53 tumor suppressor gene is a principal regulator of cancer cell proliferation. Various data have demonstrated an association between p53 and IGF-IR actions on cell growth through its’ putative regulation of IGF-IR expression. According to our performed experiments, p53 does not modify IGF-IR expression and does not affect basal MCF-7 cells adhesion onto FN. Moreover, technical details about the performance of adhesion assay onto the FN substrate were provided.