Gender difference in 5-year all-cause mortality and ACS following PCI were examined during time period of 25 years.
The female patients had higher risk profiles than the male patients in terms of age, and comorbid diseases.
Gender difference in the long-term clinical outcomes was diminished over time, despite the higher risk profiles of the female group.
Evolution of PCI and evidence-based medical therapy might offset unfavorable patient background of the female group.