In vivo imaging of estrogen receptor concentration in the endometrium and myometrium using FES PET — influence of menstrual cycle and endogenous estrogen level

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• 作者：Tatsuro Tsuchida ; Hidehiko Okazawa ; Tetsuya Mori ; Masato Kobayashi ; Yoshio Yoshida ; Yasuhisa Fujibayashi ; Harumi Itoh
• 关键词：Estrogen receptor concentration ; 16α ; -[¹⁸F]fluoro-17β ; -estradiol (FES) ; Positron emission tomography (PET) ; Menstrual cycle ; Endogenous estrogen level
• 刊名：Nuclear Medicine and Biology
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：34
• 期：2
• 页码：205-210
• 全文大小：294 K

文摘

>Purpose

The goals of this study were to measure estrogen receptor (ER) concentration in the endometrium and myometrium using 16α-[¹⁸F]fluoro-17β-estradiol (FES) positron emission tomography (PET) and to investigate the relationship between changes in these parameters with the menstrual cycle and endogenous estrogen levels.

Methods

Sixteen female healthy volunteers were included in this study. After blood sampling to measure endogenous estrogen level, FES PET image was acquired 60 min postinjection of FES. After whole-body imaging of FES PET, averaged standardized uptake values (SUVs) in the endometrium and myometrium were measured, and the relationship between FES uptake and menstrual cycle or endogenous estrogen level was evaluated.

Results

Endometrial SUV was significantly higher in the proliferative phase than in the secretory phase (6.03±1.05 vs. 3.97±1.29, P=.022). In contrast, there was no significant difference in myometrial SUV when the proliferative and secretory phases were compared (P=.23). Further, there was no correlation between SUV and endogenous estrogen level in the proliferative phase.

Conclusions

The change of ER concentration relative to menstrual cycle as characterized by FES PET was consistent with those from previous reports that used an immunohistochemical technique. These data suggest that FES PET is a feasible, noninvasive method for characterizing changes in ER concentration.