Autoradiographic evaluation of ^99mTc-methylene diphosphonate accumulation in oral cancer invading the mandible

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• 作者：Makoto Tsuchimochi ; Masataka Katagiri ; Kadzuo Maeda ; Joji Kato
• 刊名：Journal of Oral and Maxillofacial Surgery
• 出版年：1999
• 出版时间：March 1999
• 年：1999
• 卷：57
• 期：3
• 页码：245-254
• 全文大小：14896 K

文摘

Purpose: Skeletal scintigraphy, a sensitive diagnostic tool used to detect changes in bone, is helpful for evaluating bone invasion by oral cancer. However, the exact sites of accumulation of ^99mTc-phosphate compounds in the mandible have not yet been fully elucidated. The aim of this study was to determine the localization of ^99mTc-methylene diphosphonate (MDP) in the areas of mandible that have been invaded by cancer.

Patients and Methods: Seven patients with oral cancer (lower gingiva, 4; tongue, 2; floor of the mouth, 1) who underwent surgical treatment with mandibular bone resection were included in the study. Autoradiography and contact macroradiography were used for evaluation of ^99mTc-MDP accumulation.

Results: Radioactivity reflecting accumulation of ^99mTc-MDP was documented encircling the portion of the mandible with cancerous invasion, suggesting that ^99mTc-MDP accumulated in immature bone. High uptake also was found in the periosteal reactive bone around the cortical bone.

Conclusions: The amount of increased ^99mTc-MDP circumscribing carcinoma invasion varies among cases. Additionally, uptake may not correspond directly with the amount of the carcinoma invasion; that seen in periosteal bone could be attributed mistakenly to bone invasion in planar scintigraphy.