Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells
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- 作者：Ke-Hung Tsuia ; b ; 1 ; Yu-Hsiang Lina ; c ; 1 ; Li-Chuan Chungd ; Sung-Ting Chuangd ; Tsui-Hsia Fenge ; Kun-Chun Chiangf ; Phei-Lang Changa ; b ; Chi-Ju Yehg ; Horng-Heng Juanga ; d ; hhj143@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder ; PDEF ; MASPIN ; NDRG family genes ; Invasion ; Tumorigenesis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 May 2016
- 年：2016
- 卷：375
- 期：1
- 页码：142-151
- 全文大小：2689 K
文摘
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The role and function of PDEF in bladder carcinoma is still unknown.
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Our results showed that PDEF attenuated bladder carcinoma cell growth in vitro and in vivo.
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PDEF modulates gene expressions of BTG2, NDRG1, MASPIN, and KAI1.
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PDEF blocks EMT and F-actin polymerization in bladder carcinoma cells.
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We suggest that PDEF is regarded as a tumor suppressor gene in human bladder cancer.