- 作者：Akira Tsujimura ; Yasushi Miyagawa ; Kentaro Takezawa ; Hidenobu Okuda ; Shinichiro Fukuhara ; Hiroshi Kiuchi ; Tetsuya Takao ; Ryohei Yamamoto ; Makoto Nishida ; Keiko Yamauchi-Takihara ; Toshiki Moriyama ; Norio Nonomura
- 刊名：Urology
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：82
- 期：4
- 页码：814-819
- 全文大小：378 K
Objective
To clarify the probability of low serum testosterone level as a risk factor for metabolic syndrome (MS) in middle-aged men, we measured serum total testosterone (TT) and assessed several metabolic factors because the direct risk for MS has not been investigated fully in men.Methods
This study comprised 1150 men aged?¡Ý30 years. Physical and laboratory variables were assessed. Analyses were conducted to determine the association between serum TT level and incidence risk of MS and MS factors by a separate logistic regression model.
Results
Mean (¡À standard deviation [SD]) serum TT level was 5.4 ¡À 1.7 ng/mL in the 1150 men, and only 92 men (8.0 % ) were classified as having MS by the Japanese criteria. In age-adjusted analyses, higher levels of serum TT were independently associated with a lower risk of MS (odds ratio, per SD decrement of TT, 2.3; 95 % confidence interval [CI], 1.7-2.9). MS risk increased by lower quintile of TT: ORs were 15.1 (95 % CI, 4.6-50.0) for first quintile, 8.8 (95 % CI, 2.6-29.9) for second quintile, 5.8 (95 % CI, 1.7-20.5) for third quintile, and 5.0 (95 % CI, 1.4-17.9) for fourth quintile compared with highest quintile of TT. Age-adjusted ORs for the incidence of dichotomous components of MS per SD decrement of TT were 1.8 (95 % CI, 1.5-2.3) for waist circumference, 1.6 (95 % CI, 1.1-2.2) for dyslipidemia, and 1.5 (95 % CI, 1.2-1.8) for hypertension.
Conclusion
We found that higher probability of MS was associated with lower levels of serum TT level in relatively healthy middle-aged Japanese men.