Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A
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- 作者：Hirokazu Kimuraa ; b ; kimhiro@nih.go.jp" class="auth_mail" title="E-mail the corresponding author ; Koo Nagasawaa ; c ; Hiroyuki Tsukagoshid ; Yuki Matsushimae ; Kiyotaka Fujitaf ; Lay Myint Yoshidag ; Ryota Tanakah ; Haruyuki Ishiii ; Naoki Shimojoc ; Makoto Kurodaj ; Akihide Ryob
- 关键词：AICM ; Akaike's information criterion using MCMC ; BRSV ; bovine respiratory syncytial virus ; BSP ; Bayesian skyline plot ; FEL ; fixed effects likelihood ; F gene ; fusion protein gene ; F protein ; fusion protein ; G gene ; attachment glycoprotein gene ; G protein ; attachment glycoprotein ; HPD ; highest probability density ; HRSV ; human respiratory syncytial virus ; IFEL ; internal fixed effects likelihood ; MCMC ; Markov chain Monte Carlo ; MEME ; mixed effects model of evolution ; p-distance ; pairwise distance ; S
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：398-406
- 全文大小：1358 K
文摘
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The common ancestor of HRSV diverged from Bovine RSV at about 550 years ago.
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HRSV-A diverged from HRSV-B at about 280 years ago.
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The present HRSV-A strains could be phylogenetically assigned as 6 genotypes.
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Amino acid substitutions were not significantly linked to the epitope of the palivizumab.
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The effective population size of prevalent genotype increased during the last 10 years.