Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011
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- 作者：Izumi Kushibuchi ; Miho Kobayashi ; Takashi Kusaka ; Hiroyuki Tsukagoshi ; Akihide Ryo ; Ayako Yoshida ; Haruyuki Ishii ; Takeshi Saraya ; Daisuke Kurai ; Norio Yamamoto ; Kazuhiko Kanou ; Mika Saitoh ; Masahiro Noda ; Makoto Kuroda ; Yukio Morita ; Kunihisa Kozawa ; Kazunori Oishi ; Masato Tashiro ; Hirokazu Kimura
- 关键词：ARI ; acute respiratory infection ; ESS ; effective sample size ; FEL ; fixed effects likelihood ; HPD ; highest posterior density ; IFEL ; internal fixed effects likelihood ; MCMC ; Markov Chain Monte Carlo ; REL ; random effects likelihood ; RSV ; respiratory syncytia
- 刊名：Infection, Genetics and Evolution
- 出版年：2013
- 出版时间：August, 2013
- 年：2013
- 卷：18
- 期：Complete
- 页码：168-173
- 全文大小：372 K
文摘
We investigated the evolution of the C-terminal 3rd hypervariable region of G gene in the prevalent human respiratory syncytial virus (RSV) subgroups A (RSV-A) and B (RSV-B) in Japan in 2008-2011. Phylogenetic analysis and the evolutionary timescale was obtained by the Bayesian Markov Chain Monte Carlo method. All 38 RSV-A strains detected were classified into genotype NA1 and the 17 RSV-B strains detected belonged to genotypes BA and GB2. NA1 subdivided around 1998 in the present phylogenetic tree. Genotype BA subdivided around 1994. The evolutionary rates for RSV-A and RSV-B were estimated at 3.63 ¡Á 10?3 and 4.56 ¡Á 10?3 substitutions/site/year, respectively. The mean evolutionary rate of RSV-B was significantly faster than that of RSV-A during all seasons. The pairwise distance was relatively short (less than 0.06). In addition, some unique sites under positive selection were found. The results suggested that this region of the RSV strains rapidly evolved with some unique amino acid substitutions due to positive pressure.