- 作者：Nanae Tomonaga ; Yoichi Nakamura ; Hiroyuki Yamaguchi ; Takaya Ikeda ; Kosuke Mizoguchi ; Kohei Motoshima ; Seiji Doi ; Katsumi Nakatomi ; Tetsuya Iida ; Tomayoshi Hayashi ; Takeshi Nagayasu ; Kazuhiro Tsukamoto ; Shigeru Kohno
- 关键词：EGFR mutations ; Heterogeneity ; Mixed type adenocarcinoma ; Non&ndash ; small-cell lung cancer ; Smoking
- 刊名：Clinical Lung Cancer
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：14
- 期：5
- 页码：521-526
- 全文大小：1218 K
Background
Epidermal growth factor receptor mutations are predictive of the success of EGFR tyrosine kinase inhibitor treatment in patients with advanced non-small-cell lung cancer. As with other solid tumors, lung cancer is thought to be the result of an accumulation of genetic alterations after exposure to carcinogens. The aim of the present study was to clarify the relationship between multistep carcinogenesis and the accumulation of EGFR mutations.Patients and Methods
The intratumor heterogeneity of EGFR mutations was analyzed in 38 patients with resected mixed-type lung adenocarcinoma according to histological patterns, and the clinical features of the patients harboring intratumor heterogeneity of EGFR mutations were evaluated.
Results
Intratumor heterogeneity of EGFR mutations was detected in 9 of 38 tumors. EGFR mutations were more common in the bronchioloalveolar (lepidic) carcinoma pattern than in the papillary and acinar patterns, although this difference was not significant. However, there was a significant correlation between intratumor heterogeneity of EGFR mutations and smoking history (P?< .043).
Conclusion
Intratumor heterogeneity of EGFR mutations correlates with the distribution of histological subtype in mixed type adenocarcinoma and is associated with smoking history.