MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression
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- 作者：Yoshihiro Kawasaki1 ; kawasaki@iam.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Mimon Komiya1 ; Kosuke Matsumura1 ; Lumi Negishi1 ; Sakiko Suda1 ; Masumi Okuno1 ; Naoko Yokota4 ; Tomoya Osada1 ; Takeshi Nagashima2 ; Masaya Hiyoshi3 ; Mariko Okada-Hatakeyama2 ; Joji Kitayama3 ; Katsuhiko Shirahige4 ; Tetsu Akiyama1 ; 5 ; akiyama@iam.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2554-2564
- 全文大小：1492 K
文摘
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MYU is identified as a direct target lncRNA of the Wnt/c-Myc pathway
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MYU is required for the tumorigenicity of colon cancer cells
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MYU associates with the RNA-binding protein hnRNP-K to stabilize CDK6 expression
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MYU-mediated stabilization of CDK6 is critical for the growth of colon cancer cells