Single particle irradiation system to cell (SPICE) at NIRS
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- 作者：Yamaguchi ; Hiroshi ; Sato ; Yukio ; Imaseki ; Hitoshi ; Yasuda ; Nakahiro ; Hamano ; Tsuyoshi ; Furusawa ; Yoshiya ; et. al.
- 关键词：Ionizing ; Particle ; Microbeam ; Radiation biology ; Radiation protection
- 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
- 出版年：2003
- 出版时间：September, 2003
- 年：2003
- 卷：210
- 期：Complete
- 页码：292-295
- 全文大小：84.0 K
文摘
Selective irradiation by an ionizing particle of a targeted cell organelle may disclose such mechanisms as signal transaction among cell organelles and cell-to-cell communication in the processes toward an endpoint observed. Bystander effect, existence of which has been clearly evidenced by application of the particle microbeam to biological experiments, suggests potential deviation from the conventional risk estimation at low particle fluence rates, such as in an environment of space radiation in International Space Station. To promote these studies we started the construction of a microbeam facility (named as SPICE) by using our HVEE Tandem accelerator (3.4 MeV proton and 5.1 MeV 4He2+). For our primary goal, “irradiation of cell organelle with a single particle with a position resolution of 2 μm in a reasonable irradiation time”, special features are considered. Usage of a triplet Q-magnet for focussing the beam to micrometer levels is an outstanding feature compared to facilities of other institutes. Other features are almost similar to those of other institutes. Those are precise position control of a cell dish holder, design of the cell dish, data acquisition of microscopic image of a cell organelle (cell nucleus), data processing, reliable particle detection, soft and hard wares to integrate all these related data and system to control and irradiate a targeted spot with exactly determined number of particles.