Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS

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• 作者：Mitsuru Suda ; Takuya Hagihara ; Noriyoshi Suya ; Tsuyoshi Hamano ; Masashi Takada ; Teruaki Konishi ; Takeshi Maeda ; Yasushi Ohmachi ; Shizuko Kakinuma ; Kentaro Ariyoshi ; Yoshiya Shimada ; Hitoshi Imaseki
• 关键词：Accelerator ; Neutron ; Biological study ; SPF ; Dose measurement
• 刊名：Radiation Physics and Chemistry
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：78
• 期：12
• 页码：1216-1219
• 全文大小：243 K

文摘

We developed a neutron irradiation facility, neutron exposure accelerator system for biological effect experiments (NASBEE) for biological studies in National Institute of Radiological Sciences, Japan. Irradiation field of 2 MeV average neutrons generated by a Be(d–n)B reaction is established. Dose uniformity of 240 mm in diameter irradiation field is producible within ±2.5 % with a dose rate of 0.87 Gy/h at sample target distance of 1170 mm. Two irradiation rooms, a specific pathogen-free (SPF) conditioned one and a conventional, are now available. Irradiation protocols for in vitro experiments are now established and demonstrated by obtaining a relative biological effectiveness (RBE) of cell inactivation measured to be 3.54 with 10 % survival dose (D₁₀).