Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: An open-label study

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• 作者：Tsuyoshi Miyaoka ; Motohide Furuya ; Hideaki Yasuda ; Maiko Hayashida ; Akira Nishida ; Takuji Inagaki ; Jun Horiguchi
• 关键词：Schizophrenia ; Tardive dyskinesia ; Yi-gan san ; 5-HT2A antagonism
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2008
• 出版时间：1 April 2008
• 年：2008
• 卷：32
• 期：3
• 页码：761-764
• 全文大小：129 K

文摘

Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia.

Methods

Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study.

Results

Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms.

Conclusions

YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.